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    Do not take SPRAVATO® if you:

    have blood vessel (aneurysmal vascular) disease (including in the brain, chest, abdominal aorta, arms and legs)
    have an abnormal connection between your veins and arteries (arteriovenous malformation)
    have a history of bleeding in the brain
    are allergic to esketamine, ketamine, or any of the other ingredients in SPRAVATO®.
    If you are not sure if you have any of the above conditions, talk to your healthcare provider before taking SPRAVATO®